Asthma as a chronic infection. Effect of cortison spray.
Question:
> > > See last words "Our results do not indicate an increased risk of > > diabetes among current users of inhaled corticosteroids." (and > > first words "There is evidence that large doses of inhaled > > corticosteroids lead to an increased risk of glaucoma, cataracts > > and other problems associated with oral corticosteroid use.") > Especially read the word "large." > The crux of the matter is, how is an ordinary user to know what dose > of inhaled corticosteroids is "large"? Are we to presume that any > prescribed amount will not be large?
An ordinary user has his doctor(s) to consult. If you don’t trust your doctor to be both giving you proper medication in proper doses _and_ keeping up with the current literature, find another doctor. -S-
Response:
> > See last words "Our results do not indicate an increased risk of > diabetes among current users of inhaled corticosteroids." (and > first words "There is evidence that large doses of inhaled > corticosteroids lead to an increased risk of glaucoma, cataracts > and other problems associated with oral corticosteroid use.") > Especially read the word "large."
The crux of the matter is, how is an ordinary user to know what dose of inhaled corticosteroids is "large"? Are we to presume that any prescribed amount will not be large? — (650) 236-2231 [daytime] http://www.wsrcc.com/alison/ Stay tuned. Technicians are working on the problem.
Response:
– Hide quoted text — Show quoted text -> > See last words "Our results do not indicate an increased risk of > > diabetes among current users of inhaled corticosteroids." (and > > first words "There is evidence that large doses of inhaled > > corticosteroids lead to an increased risk of glaucoma, cataracts > > and other problems associated with oral corticosteroid use.") > Especially read the word "large." > The crux of the matter is, how is an ordinary user to know what dose > of inhaled corticosteroids is "large"? Are we to presume that any > prescribed amount will not be large?
You could look it up or ask. Ellis has posted the information about a billion times. — CBI, MD
Response:
> See last words > "Our results do not indicate an increased risk of diabetes among current > users of inhaled corticosteroids." > (and first words "There is evidence that large doses of inhaled > corticosteroids lead to an increased risk of glaucoma, cataracts and > other problems associated with oral corticosteroid use.")
Especially read the word "large." — CBI, MD
Response:
See last words "Our results do not indicate an increased risk of diabetes among current users of inhaled corticosteroids." (and first words "There is evidence that large doses of inhaled corticosteroids lead to an increased risk of glaucoma, cataracts and other problems associated with oral corticosteroid use.") – Hide quoted text — Show quoted text -> Eur Respir J 2002 > Mar;19(3):546-56 (per Medline ) > Role of persistent infection in the control and severity of asthma: > focus on Chlamydia pneumoniae. > This protein is able to elicit a strong host inflammatory response at > sites of its production and appears to be involved in tissue injury and > scarring processes. As inflammation has been found to be present in > almost all asthmatics, whatever the severity and aetiology of the > disease, inhaled glucocorticoids now have an established position in the > treatment of early stages. However, corticosteroids negatively affect > many aspects of cell-mediated immunity and favour the shift from a > T-helper-1-type response towards a T-helper-2-type response. > Corticosteroids may thus severely deteriorate the host’s ability to > eradicate an intracellular pathogen, such as Chlamydia pneumoniae, which > requires a properly functioning cell-mediated (T-helper-1-type) immune > response to be cleared. These drugs are also able to reactivate > persistent Chlamydia to an active growth phase, which, by increasing the > production of pro-inflammatory cytokines at the site of infection, can > further amplify inflammation in the airways of patients with asthma. > Regards, Richard Friedel > May also cause cataract’s and diabetes…see attached > http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&… > ds=12100226&dopt=Abstract > Regards > Mark
Response:
Eur Respir J 2002 Mar;19(3):546-56 (per Medline ) Role of persistent infection in the control and severity of asthma: focus on Chlamydia pneumoniae. This protein is able to elicit a strong host inflammatory response at sites of its production and appears to be involved in tissue injury and scarring processes. As inflammation has been found to be present in almost all asthmatics, whatever the severity and aetiology of the disease, inhaled glucocorticoids now have an established position in the treatment of early stages. However, corticosteroids negatively affect many aspects of cell-mediated immunity and favour the shift from a T-helper-1-type response towards a T-helper-2-type response. Corticosteroids may thus severely deteriorate the host’s ability to eradicate an intracellular pathogen, such as Chlamydia pneumoniae, which requires a properly functioning cell-mediated (T-helper-1-type) immune response to be cleared. These drugs are also able to reactivate persistent Chlamydia to an active growth phase, which, by increasing the production of pro-inflammatory cytokines at the site of infection, can further amplify inflammation in the airways of patients with asthma. Regards, Richard Friedel
Response:
– Hide quoted text — Show quoted text -> Eur Respir J 2002 > Mar;19(3):546-56 (per Medline ) > Role of persistent infection in the control and severity of asthma: > focus on Chlamydia pneumoniae. > This protein is able to elicit a strong host inflammatory response at > sites of its production and appears to be involved in tissue injury and > scarring processes. As inflammation has been found to be present in > almost all asthmatics, whatever the severity and aetiology of the > disease, inhaled glucocorticoids now have an established position in the > treatment of early stages. However, corticosteroids negatively affect > many aspects of cell-mediated immunity and favour the shift from a > T-helper-1-type response towards a T-helper-2-type response. > Corticosteroids may thus severely deteriorate the host’s ability to > eradicate an intracellular pathogen, such as Chlamydia pneumoniae, which > requires a properly functioning cell-mediated (T-helper-1-type) immune > response to be cleared. These drugs are also able to reactivate > persistent Chlamydia to an active growth phase, which, by increasing the > production of pro-inflammatory cytokines at the site of infection, can > further amplify inflammation in the airways of patients with asthma. > Regards, Richard Friedel
May also cause cataract’s and diabetes…see attached http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&… ds=12100226&dopt=Abstract Regards Mark
Response:
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